Inborn metabolic disorders causing hyperbilirubinemia


  • Hereditary or inborn metabolic disorders may cause unconjugated or conjugated hyperbilirubinemia (see Overview of bilirubin metabolism).

    Unconjugated hyperbilirubinemia: Crigler-Najjar syndrome, Gilbert syndrome, and primary shunt hyperbilirubinemia
    Conjugated hyperbilirubinemia: Dubin-Johnson syndrome and Rotor syndrome

    (See also Liver Structure and Function and Evaluation of the Patient with a Liver Disorder.)


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