Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Wee-weed
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A mildly derisive euphemism related to pissed off but with a suggestion of childhood nervous incontenence or bedwetting. Suggests a loss of control from fear or anxiety as much as anger. Dont get wee-weed up over it is similar to dont wet your pants. Origin is the childhood term wee-wee, to urinate.
Wee-weed meaning & definition 1 of Wee-weed.
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