• An abbreviation for Designated Ugly Fat Friend. Often in many large groups of women (usually adolecents) there will be a D.U.F.F. as a means to look better by comparison.


    D.u.f.f. meaning & definition 1 of D.u.f.f..


  • The Designated (/Dumb) Ugly Fat Friend.

    The cock-blocking friend of the hot chick youre trying to hook up with, often the target of the wingman.

    D.u.f.f. meaning & definition 2 of D.u.f.f..

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