Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Stingo
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Old beer; sharp or strong liquor. [Old Slang]Shall I set a cup of old stingo at your elbow Addison.
Stingo meaning & definition 1 of Stingo.
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Stingo (or STIngo) is a game of chance in which players strategically acquire veneral diseases to make a line of randomly assigned [STI]s join up on the back of a clinic appointment card.
Stingo meaning & definition 2 of Stingo.
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A young girl who thinks she is, in her own words, the best even though she will continually choose the easy option in life and still fail; she has a user-mentality and 99% of all decisions are [bad decisions] that if she later on fails to have the [hindsight] to regret other people will - but she doesnt care - because she only cares about herself.
e.g some one who masquerades around as being a nice person when in actual fact they are nothing more than a selfish failure. (and [a smelly] little bitch)Stingo meaning & definition 3 of Stingo.
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Capable of storing all your prospects and customers, make calls, send emails, create reports, and schedule appointments. A software product by Stingo
Stingo meaning & definition 4 of Stingo.