Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Crast
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A distraction or collection of distractions that keep one from achieving an intended task.
A population crastinates or has crastinated when a majority of their time is spent engaging in activities not even remotely productive.
When a population favors their crastinated state of mindless entertainment with little or no interaction required over a properly functioning society, they are said to be Pro-crastination
Crast meaning & definition 1 of Crast.
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can be used in replace of some words such as shit and fuck or anything else after something dumb has occured to oneself
Crast meaning & definition 2 of Crast.
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Abosultly Nothing at all.
Crast meaning & definition 3 of Crast.
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One of the most badass motherfuckers to ever live on this planet!
Crast meaning & definition 4 of Crast.
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