Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Coolers
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singular- cooler
One solid alcoholic beverage that contains .5% alchol. This beverage is the biggest wankster drink ever. Commonly sold at such stores as IGA, this drink is the best wannabe drink of all time.
Coolers meaning & definition 1 of Coolers.
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n. Surfers rappers and others who think they is cool.
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Coolers meaning & definition 2 of Coolers.
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An obscure way of saying sunglasses.
Coolers meaning & definition 3 of Coolers.
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