Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Pilgrimage
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The journey of a pilgrim; a long journey; especially, a
journey to a shrine or other sacred place. Fig., the journey of human
life.
Pilgrimage meaning & definition 1 of Pilgrimage.
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A journey with an important purpose.
Pilgrimage meaning & definition 2 of Pilgrimage.
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A kick ass [Nine Inch Nails] instrumental song.
Pilgrimage meaning & definition 3 of Pilgrimage.
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slang for going to lay a huge brick, in some unexpecting loo.
Pilgrimage meaning & definition 4 of Pilgrimage.
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a special journey made by a pilgrim:
Pilgrimage meaning & definition 5 of Pilgrimage.
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A pilgrims journey.
Pilgrimage meaning & definition 6 of Pilgrimage.
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