A striped racer, also known as the California whipsnake, is a species of non-venomous snake native to the coast and foothills of California. It is a long, slender, and fast-moving snake, identified by its distinctive stripes running down the length of its body. They primarily feed on lizards and small rodents. The scientific name for this species is Masticophis lateralis.
Prothrombin (factor ii) 20210 gene mutation
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A genetic mutation causes increased plasma levels of prothrombin (factor II), predisposing to venous thrombosis.
(See also Overview of Thrombotic Disorders.)
Prothrombin (factor II) is a vitamin K-dependent precursor of thrombin, the terminal enzyme of the coagulation cascade (see figure Pathways in blood coagulation). A single nucleotide mutation in one (or, less commonly, both) of the prothrombin genes at position 20210 results in increased plasma prothrombin levels (with potentially increased thrombin generation) and increases the risk of venous thromboembolism.
The prevalence of the mutation ranges from lt; 1% to 6.5%, depending on the population studied.
The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples.
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