Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Flatten
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To lower the pitch of; to cause to sound less sharp; to letfall from the pitch. To flatten a sail (Naut.), to set it more nearlyfore-and-aft of the vessel.-- Flattening oven, in glass making, a heated chamber in which splitglass cylinders are flattened for window glass.
Flatten meaning & definition 1 of Flatten.
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to [crush] an object down from a greater size to a smaller one.
to make [roadkill] of a person while playing an FPS such as [halo] or [battlefield].Flatten meaning & definition 2 of Flatten.
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Make or become flat or flatter.
Flatten meaning & definition 3 of Flatten.
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to become level or cause something to become level:
Flatten meaning & definition 4 of Flatten.
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