Port St. Lucie, Florida is conveniently located near several major airports, providing travelers with easy access to the region. The closest airport to Port St. Lucie is the Treasure Coast International Airport, situated just a short drive away. This airport offers both domestic and international flights, making it a convenient option for travelers from all over the world. Additionally, Palm Beach International Airport is another nearby option, located approximately 45 minutes south of Port St. Lucie.