Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Islander
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People that came from island tribes.
ex: philippines,indonesia,malaysia. <- malayo-polynesian
palauans,guamanians,etc <- micronesians
papuans,soloman islanders,etc <- melanesians
samoans,native hawaiians,tongans,etc <- polynesians
and many other places in asia pacific and north america that were inhabited by island tribes.
Islander meaning & definition 1 of Islander.
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A native or inhabitant of an island.
Islander meaning & definition 2 of Islander.
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Prince Edward Islander. No one refers to them as islanders except themselves. Anne of Green Gables has become a modern deity to these humble folk, all of whom either work in the tourism industry or grow potatos.
Islanders speak fairly normal english, with a few peculiar twists. Words like bagel and dad are consistently pronounced improperly. They also have no concept of a backpack or knapsack, instead prefering to use queer little articles they lovingly refer to as kitbags.
To be fair, all islanders who venture forth from the Island are good people and make great companions. Though a strange breed, they bring enrichment to the historically incestuous regions of Eastern Canada.Islander meaning & definition 3 of Islander.
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When you shit so much it rises above the water in the toilet bowl. This should look like a large island has been created.
Islander meaning & definition 4 of Islander.
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a small minded person, usually from the island of Prince Edward.
Being an islander is the reproduction from the mating of two genetically related parents, which can increase the chances of offspring being affected by recessive or deleterious traits. This generally leads to a decreased fitness of a population, which is called inbreeding depression.
People who like to talk about everyone else but themselves;
Gossip whores
Liberals who steal legallyA premier who likes chicks with dicks
Islander meaning & definition 5 of Islander.
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lesbian.
a reference to the island of lesbos, where sappho livedIslander meaning & definition 6 of Islander.
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someone who lives on an island:
Islander meaning & definition 7 of Islander.