Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Sleepiness
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Often a general lack of energy, even after an adequate night time sleep caused mainly by boring college classes or nothing to do. It is very common to young adults and teenagers.
Sleepiness meaning & definition 1 of Sleepiness.
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the feeling of being tired and wanting to sleep:
Sleepiness meaning & definition 2 of Sleepiness.
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