Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Big eye
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When you are super hungry and EVERYTHING looks good. When you order tons of stuff to eat, only to find out afterwards that you werent as hungry as you thought you were. e.g. your eyes are bigger than your stomach.
Big eye meaning & definition 1 of Big eye.
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having big eye refers to being in the weeds or overwhelmed to an extreme level.
Big eye meaning & definition 2 of Big eye.
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Term used when taking ecstasy etc, when your pupils are so big there isnt much colour to be seen.
Big eye meaning & definition 3 of Big eye.
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A street drug that makes people act like their aint a problem in the world.
Big eye meaning & definition 4 of Big eye.
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Used mainly in the south to mean you cannot sleep or you have the big eye
Big eye meaning & definition 5 of Big eye.
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