Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Celebrities
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They are full of self-delusion, hypocrisy and attention seeking drug habits. They are spoiled drama queens and usually have absolutely no idea what theyre talking about because theyre under-educated. They drive cars that cost enough to feed a small country. They provide nothing practical to society and pack-rat millions of dollars all the while claiming to be enlightened humanitarians and giving away a few thousand dollars to charity which they could just as well wipe their ass with.
Celebrities meaning & definition 1 of Celebrities.
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[The tards] [flapping] about on MTV, admired by girls aged 11-18 and anyone else with their mobile phone up their ass. Nobody should be obsessed over celebrities and if they are they are either a) a girl or b) a [sped].
Celebrities meaning & definition 2 of Celebrities.
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someone who is famous, especially in the entertainment business
Celebrities meaning & definition 3 of Celebrities.