Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Drainer
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noun.
A person or thing that for some reason (e.g. for being annoying, a whinger, a loser, or boring, etc.) drains ones energy and general enjoyment of life.
Drainer meaning & definition 1 of Drainer.
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Someone who puts people down by continually offloading their problems into them. They can often masquerade as a friend but their intentions are not friendly.
Drainer meaning & definition 2 of Drainer.
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a person who explores/skates in/sleeps in/travels through underground drains, tunnels or sewers
Drainer meaning & definition 3 of Drainer.
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A word used to decribe Females who arnt worthy of anything more than sex, a girl who you wouldnt consider a relationship with, Someone you only would sleep with and no more!
Drainer meaning & definition 4 of Drainer.
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paraphernalia made out of plastic bottle used for smoking weed. How to make : Using a lighter to implant a metal socket into the center of a plastic bottle (Usually Power/Gatorade) cap. Then melting a small hole on the side at the bottle of the bottle. Fill the socket with weed and the bottle with water. Light and let water drain out of bottom hole at the same time to fill with smoke.
Drainer meaning & definition 5 of Drainer.
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When your with a few mates having a smoke and just jammin, theres always that one person that holds the spliff and CHUUUFFS it down.
This person is the [drainer].
Drainer meaning & definition 6 of Drainer.
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when a woman sits her vagina on a drain, letting the vaccuuming force suck out her insides
Drainer meaning & definition 7 of Drainer.
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A device used for draining things.
Drainer meaning & definition 8 of Drainer.