Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cock shy
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a person too frightened to have a sexual encounter
a sex game where three males with erections stand in formation and the opposing team throw ring doughnuts over the erections - like quoits
Cock shy meaning & definition 1 of Cock shy.
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Entering a public restroom for a quick wizz and upon seeing other men at the urinal, opting to use the stalls instead. Usually implies one has a small penis.
Cock shy meaning & definition 2 of Cock shy.
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A male (usually teenaged) who is pathologically shy about exposing his genitals to other males such as when stripping off in locker room and/or showering publically with other men at a public facility. Someone afflicted with cock shyness is often a mommys boy with a low bodily self-esteem and poor social skills. These poor fellows will often change into their sports gear at home and leave after the game to shower elsewhere.
Cock shy meaning & definition 3 of Cock shy.