Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Attachments
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A metaphor for balls as coined by David Hobbs of SPEED during a Formula 1 broadcast.
Attachments meaning & definition 1 of Attachments.
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[Thirst] [traps] or [nudes] sent
Attachments meaning & definition 2 of Attachments.
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an extra piece of equipment that can be added to a machine:
Attachments meaning & definition 3 of Attachments.
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