Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Thunderous
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Making a noise like thunder; sounding loud and deep;
sonorous.
Thunderous meaning & definition 1 of Thunderous.
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Relating to or resembling thunder.
Thunderous meaning & definition 2 of Thunderous.
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(adj.) To play very poorly in a video game, as if [not knowing] how to play the video game; a [newcomer] that doesnt know how to play the video game; often dying and being [a burden] to the team.
Chinese: 雷友Thunderous meaning & definition 3 of Thunderous.
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