Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Hosier
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One who deals in hose or stocking, or in goods knit or
woven like hose.
Hosier meaning & definition 1 of Hosier.
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an extermly loud fat man on the teacher commitee in florida deca; a jackass; an extemly inconsiderate person
Hosier meaning & definition 2 of Hosier.
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A term used to define someone from the Midwest portion of the United States (i.e; Americas Heartland). Generally used in a joking manner, but can be used as an insult depending on the tone in which it is used.
Hosier meaning & definition 3 of Hosier.
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