Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Half-chub
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An inkling of an erection. 1/2 a chubby, therefore 1/4 a full erection.
Half-chub meaning & definition 1 of Half-chub.
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A half erect penis, either a result of being only partialy aroused, or being paranoid of being caught.
Half-chub meaning & definition 2 of Half-chub.
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since a chub is a full erection that is thick in girdth, but not proportionate in length; a half chub describes anything between flacid and an all out boner.
Half-chub meaning & definition 3 of Half-chub.
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