Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
X marks the spot
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What is said upon finding your target has been marked out. Derived from an X on pirate treasure maps. The phrase was put into common usage by the British army, who performed executions by marking a piece of paper with a black x and positioning it on the heart of someone sentenced to death.
The acting officer would say X marks the spot and the firing squad would shoot the x.
X marks the spot meaning & definition 1 of X marks the spot.
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This is the exact location (from the act of using an x to mark a location on a map)
X marks the spot meaning & definition 2 of X marks the spot.
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You let cookies and cream ice cream melt in your mouth, reserving a large cookie piece. Each person in the circle sticks out their tongues and the person with the largest cookie piece, or x marks the spot, wins the round.
X marks the spot meaning & definition 3 of X marks the spot.
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This is when you bury some poor soul in the sand usually at the beach with their face exposed then you drop your drawers and you take a huge shit on their face.
X marks the spot meaning & definition 4 of X marks the spot.
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a sexual position where an individual lays on the ground and makes an x with his or her body.
then inserts each of his or her hands and feet into four consenting women.
X marks the spot meaning & definition 5 of X marks the spot.
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shaving ones pubes like an X
X marks the spot meaning & definition 6 of X marks the spot.