Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
So long
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So Long comes from the ghettoes of New York where irish,italian Jewish and Arab immigrants mixed together. Jews and Arabs always greet and say goodbye to each other by saying Shalom,Shalom, or Salaam,Salaam. These words were corrupted into solong, solong. Ultimately folks believed that it meant that it had been so long since you had seen someone. Not so.
So long meaning & definition 1 of So long.
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the way to say goodbye..
So long meaning & definition 2 of So long.
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