Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Glhf
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glhf, an acronym for good luck have fun
Glhf meaning & definition 1 of Glhf.
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Good luck, have fun.
Glhf meaning & definition 2 of Glhf.
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An acronym, which stands for Good luck, have fun. Meant as a salutation at the beginning of a game, usually a sign of good will.
Glhf meaning & definition 3 of Glhf.
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Acronym for Good luck, have fun
Glhf meaning & definition 4 of Glhf.
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Good [Lyfe], [High Five]
[Verb]Glhf meaning & definition 5 of Glhf.
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[Gravy] [laden] hand fuck.
When one is given a usually high intensity hand job, by a hand covered in brown or [white gravy].
While often terribly messy, they are great fun.
Glhf meaning & definition 6 of Glhf.
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