Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Schmeckle
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Yiddish term for penis.
Schmeckle meaning & definition 1 of Schmeckle.
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not 100% sure of spelling
hebrew/yiddish slang for a small penis
Schmeckle meaning & definition 2 of Schmeckle.
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A currency shared in all dimensions.
Schmeckle meaning & definition 3 of Schmeckle.
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the last bits of weed in the bottom of the bowl, not enough for a cone
Schmeckle meaning & definition 4 of Schmeckle.
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- penis
- junk
- his package
- idiot
Schmeckle meaning & definition 5 of Schmeckle.
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dick head, some times confused with shmuck
Schmeckle meaning & definition 6 of Schmeckle.
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To thump one in the head with ones penis.
Schmeckle meaning & definition 7 of Schmeckle.
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Big long hairy thing that gets the tip cut off at a briss. (See Penis)
Schmeckle meaning & definition 8 of Schmeckle.
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Term used from one another to beckon a kiss
Schmeckle meaning & definition 9 of Schmeckle.
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