Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Meth head
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(METH hed) n. a user of methamphatamine syn: [speed freak], [tweaker], [sketcher]
Meth head meaning & definition 1 of Meth head.
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This term is used to describe the lowest form of drug addict scum there is. You know your in ones presence when you can count the teeth they have on one hand and they chop their parents basement furniture up with an axe in the yard. Beware they will steal from their own parents, fuck over drug dealers and be held hostage with assault rifles.
Meth head meaning & definition 2 of Meth head.
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