Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Lock and load
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(verb expression) Short for locking the magazine/cartridge into the gun and loading the ammunition into the guns chamber. (Usu. used to show toughness, ambition, fear and other strong characteristics. Originally spoken by John Wayne in Sands of Iwo Jima as load and lock.)
Lock and load meaning & definition 1 of Lock and load.
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To adjust a womans [boobs] into a high and central location on the chest and hold with a garment such as a vest or short jacket.
Lock and load meaning & definition 2 of Lock and load.
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When a female intentionally gets pregnant by her boyfriend, or a guy shes interested in to make sure that the guy is a part of her life forever, usually via marriage.
Lock and load meaning & definition 3 of Lock and load.
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to [make out]or [kick it] in Marinas words...haha so LOCK AND LOAD!
Lock and load meaning & definition 4 of Lock and load.
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to [make out]or [kick it] in Marinas words...haha so LOCK AND LOAD!
Lock and load meaning & definition 5 of Lock and load.
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[Lock And Load] originated in the Vietnam era. It is in reference to the [M-16] rifle, [Lock And load]: the act of using the charging handle locking [the bolt] carrier in the open chamber position and loading the magazine into the magazine well.
Lock and load meaning & definition 6 of Lock and load.