Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Roflmao
-
This Awsome Accumulation of letters means Rolling on Floor Laughing My Ass Off
Roflmao meaning & definition 1 of Roflmao.
-
Rolling
On the
Floor
Laughing
My
Ass
OffRoflmao meaning & definition 2 of Roflmao.
-
Short for Rolling On the Floor Laughing My Ass Off. Often used in online chat rooms. Also an amusing thing to name a cat when pronounced as a word.
Roflmao meaning & definition 3 of Roflmao.
-
ROFL = Rolling On Floor Laughing
LMAO = Laughing My Ass Off
ROFL LMAO = ROFLMAO
ROFLMAO = Rolling On Floor Laughing My Ass OffRoflmao meaning & definition 4 of Roflmao.
-
Internet slang for Rolling On (the) Floor Laughing My Ass Off. Usually used when LOL just isnt enough. There have been cases of which people have added an F to the acronym. Thus being ROFLMFAO A.K.A Rolling on (the) Floor Laughing My F*cking Ass Off.
Roflmao meaning & definition 5 of Roflmao.
-
A ridiculous over statement used when people actually are not Rolling on the floor laughing (their) ass off
In reality, it means:
Really, Only Fibbing. Looking Moderately Amused Only.
Roflmao meaning & definition 6 of Roflmao.
-
Abbreviation for rolling on the floor laughing my ass off. Used by internet geeks for maximum effectiveness in laughing.
Roflmao meaning & definition 7 of Roflmao.
-
Stands for
Rolling On Floor Laughing [My Ass Off]
Used when texting, [AIMing], other forms of [social networking]...
Roflmao meaning & definition 8 of Roflmao.