Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
What's up
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An extremely annoying question that has (unfortunately) replaced Hello or Hi as the most popular form of casual greeting. For full effect, best delivered while walking past someone at about 90 m.p.h. so the person youre talking to has no time to respond, and in a tone that suggests you really dont give a shit about whats up with them.
What's up meaning & definition 1 of What's up.
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