Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Aspire
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Aspire: To have a great ambition or ultimate goal; desire strongl
Aspire meaning & definition 1 of Aspire.
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Direct one
Aspire meaning & definition 2 of Aspire.
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To perspire around the area of the anus. Usually occurs between cheeks in temperate conditions or during excercise. More likely to occur in fat people.
Leads to loss of body fluids, resulting in the need for [rehydration].
Has been known to leave an arse-shaped residue on plastic chairs, which may lead to public humiliation, social [disintegration] and polarisation. Be warned.
Alternative spelling; [asspire]Aspire meaning & definition 3 of Aspire.
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Gain full visibility into your business, make better decisions and increase profit margins with Aspires landscape management software. A software product by Aspire Software
Aspire meaning & definition 4 of Aspire.
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Agency management system with built-in marketing, text messaging, and more tools that let users manage clients, vendors, and employees. A software product by Impowersoft
Aspire meaning & definition 5 of Aspire.