Crankles

[Sarah]

Crusty and Ankles being compounded into one word.
Somebody with a unusual amount of crust on their ankles.

[Dave Paprocki]

Crankles: unusually skinny, bony ankles, which in comination with other observable traits, may indicate habitual use of methampetamine, also known as crank. A crank skank, for example, would likely have crankles. Derived from the term cankles - its opposite.

[Tanya Shivari]

The condition which usually afflicts large ladies where the ankle and calf are nearly the same diameter

[Sonia]

When youre cranky, and grumpy, and are just flat out pissy.