Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Sweepers
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Referring to a lady's breasts which are utterly saggy. These breasts will normally face directly downwards and resemble empty plastic bags. They are most commonly found on old women and pictures of African tribes women who have never heard of a bra and have breast fed 58 infants.
Sweepers meaning & definition 1 of Sweepers.
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High school english teacher whose monotone voice often lulls one to sleep in each and every class.
Sweepers meaning & definition 2 of Sweepers.
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