Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dickens
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The devil. [A vulgar euphemism.]I can not tell what the dickens his name is. Shak.
Dickens meaning & definition 1 of Dickens.
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Similar but differing slightly to the term 'twat', a Dickens is a pompous and awkward bastard who will go out of his way to needlessly berate his fellow man. Owing to the Dickens' overinflated sense of self importance the term is almost exclusively applied to ex public school boys. Often a Dickens will have been subjected to repeated bummings as a choir boy resulting in frequent pegging throughout his adult life.
Dickens meaning & definition 2 of Dickens.
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Euphemistic expression for the devil. Used in mild oaths.
Also spelt dickins/Dickens.Dickens meaning & definition 3 of Dickens.
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(noun) Any kind of a law enforcement officer who can levy a buzzkill. A cop, etc.
Dickens meaning & definition 4 of Dickens.
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abbreviation of time-in-the-past-when-I-was-kicked-directly-in-the-dick-and-balls; first shortened to dick-and-balls and then to dick-ands, and finally to dickens
Dickens meaning & definition 5 of Dickens.
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Dickens meaning & definition 6 of Dickens.
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To do something with speed and neccesity.
Dickens meaning & definition 7 of Dickens.
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Used for emphasis, or to express annoyance or surprise when asking questions.
Dickens meaning & definition 8 of Dickens.