Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Squeak
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A sharp, shrill, disagreeable sound suddenly utered, either ofthe human voice or of any animal or instrument, such as is made bycarriage wheels when dry, by the soles of leather shoes, or by a pipeor reed.
Squeak meaning & definition 1 of Squeak.
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A sound I hear repeatedly every night from my parents bedroom.
Squeak meaning & definition 2 of Squeak.
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a person who is annoying because they act child like; and or a person who is annoying because they are unskilled and unexpierenced in certain things.
Squeak meaning & definition 3 of Squeak.
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Squeak is someone who is a little bitch for someone,or someone extremly cool and is everyone friends
Squeak meaning & definition 4 of Squeak.
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The sound your adorable girlfriend makes when she's laughing! Sometimes she does it when she's scared, and she gets angry when you tell her about it!
Squeak meaning & definition 5 of Squeak.
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That [nickname] you give the coolest guy in the world after he mistakes a bed for a girl.
Squeak meaning & definition 6 of Squeak.
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vb. n.
to squeak.vb. to copulate in a not so vulgar manner, esp. with someone you dont
Squeak meaning & definition 7 of Squeak.
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When a man ejaculates on the door handle of a shower in a caravan park and then proceeds to get the shakes
Squeak meaning & definition 8 of Squeak.
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noun. To affectionately pinch someone softly. (taken from squeaking a dog's toy in a playful way)
Squeak meaning & definition 9 of Squeak.
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The motherfucking man, resides right outside of good old Kennett Square, PA. Has a sexy female roommate and puffs the best 'dro you know. Loves rap, cars and girls, nice girls not smuts.
Squeak meaning & definition 10 of Squeak.
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A [squeak] is the act of [puffing] a smaller than average vape (ex: [Juul], STLTH, etc.).
Squeak meaning & definition 11 of Squeak.
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A short, high-pitched sound or cry.
Squeak meaning & definition 12 of Squeak.
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A term used for a short time, although not [exact], meant to replace the words little, or[bit] can also be a synonym for [scoach]
Squeak meaning & definition 13 of Squeak.