Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Pullback
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The iron hook fixed to a casement to pull it shut, or to holdit party open at a fixed point.
Pullback meaning & definition 1 of Pullback.
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Slang for an uncircumcised penis derived by the action of pulling back the foreskin literally before intercourse, urination, or docking.
Pullback meaning & definition 2 of Pullback.
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an uncircumcised male
Pullback meaning & definition 3 of Pullback.
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the act of pulling back the skin of the Penis for enjoyment
Pullback meaning & definition 4 of Pullback.
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Someone whos not [circumsized] . they have to [pull] skin back to [pee] materbate and etc.
Pullback meaning & definition 5 of Pullback.
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An act of withdrawing troops.
Pullback meaning & definition 6 of Pullback.
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a reduction in the amount of money that a company or person spends:
Pullback meaning & definition 7 of Pullback.
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