Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gowk
-
To make a, booby of one); to stupefy. [Obs.] B. Jonson.
Gowk meaning & definition 1 of Gowk.
-
Gowk (pronounced ɡaʊk) is a noun with a number of meanings. It is sometimes used to mean a cuckoo or an [awkward], [clumsy] or [stupid] person. Apparently the word goes back to ancient German and could mean a [bastard], [simpleton], or fool, which gives its commonest usage namely an awkward or foolish person. There is also a third totally distinct meaning; in [Geordie] dialect it means an apple core.
Gowk meaning & definition 2 of Gowk.
-
a simpleton, someone without much sense or brains.
Gowk meaning & definition 3 of Gowk.
-
The middle, normally inedible part, of a fruit or vegetable, containing seeds etc.
Gowk meaning & definition 4 of Gowk.
Similar Words