Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fumed oak
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Oak given a weathered appearance by exposure in an air-tightcompartment to fumes of ammonia from uncorked cans, being first givena coat of filler.
Fumed oak meaning & definition 1 of Fumed oak.
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