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Causes of hepatitis

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Kai
last edited by admin

Hepatitis is an inflammation of the liver characterized by diffuse or patchy necrosis.
Hepatitis may be acute or chronic (usually defined as lasting gt; 6 months). Most cases of acute viral hepatitis resolve spontaneously, but some progress to chronic hepatitis.
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Causes of hepatitis meaning & definition 1 of Causes of hepatitis.

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Hepatitis B is caused by a DNA virus that is often parenterally transmitted. It causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice. Fulminant hepatitis and death may occur. Chronic infection can lead to cirrhosis and/or hepatocellular carcinoma. Diagnosis is by serologic testing. Treatment is supportive. Vaccination is protective and postexposure use of hepatitis B immune globulin may prevent or attenuate clinical disease.
(See also Causes of Hepatitis, Overview of Acute Viral Hepatitis, and Chronic Hepatitis B.)
Hepatitis B virus (HBV) is the most thoroughly characterized and complex hepatitis virus. The infective particle consists of a viral core plus an outer surface coat. The core contains circular double-stranded DNA and DNA polymerase, and it replicates within the nuclei of infected hepatocytes. A surface coat is added in the cytoplasm and, for unknown reasons, is produced in great excess.
HBV is the 2nd most common cause of acute viral hepatitis after hepatitis A. Prior unrecognized infection is common but is much less widespread than that with hepatitis A virus. In the US, 3218 cases of acute hepatitis B infection were reported in 2016—a decrease from the 25,000 annual cases reported before use of hepatitis B vaccine became widespread. However, because many cases are not recognized or not reported, the Centers for Disease Control and Prevention (CDC) estimates that the actual number of new infections was about 20,900 in 2016 (1).
HBV, for unknown reasons, is sometimes associated with several primarily extrahepatic disorders, including polyarteritis nodosa, other connective tissue diseases, membranous glomerulonephritis, and essential mixed cryoglobulinemia. The pathogenic role of HBV in these disorders is unclear, but autoimmune mechanisms are suggested.
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Hepatitis C is caused by an RNA virus that is often parenterally transmitted. It sometimes causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice but may be asymptomatic. Fulminant hepatitis and death rarely occur. Chronic hepatitis develops in about 75% and can lead to cirrhosis and rarely hepatocellular carcinoma. Diagnosis is by serologic testing. Treatment is supportive. No vaccine is available.
(See also Causes of Hepatitis, Overview of Acute Hepatitis, and Chronic Hepatitis C.)
In the US, almost 3000 cases of acute hepatitis C infection were reported in 2016. However, because many cases are not recognized or not reported, the Centers for Disease Control and Prevention (CDC) estimates that the actual number of new infections was over 41,000 in 2016 (1).
Hepatitis C virus (HCV) is a single-stranded RNA flavivirus that causes acute viral hepatitis and is a common cause of chronic viral hepatitis. Six major HCV subtypes exist with varying amino acid sequences (genotypes); these subtypes vary geographically and in virulence and response to therapy. HCV can also alter its amino acid pattern over time in an infected person, producing quasispecies.
HCV infection sometimes occurs simultaneously with specific systemic disorders, including the following:

Essential mixed cryoglobulinemia
Porphyria cutanea tarda (about 60 to 80% of porphyria patients have HCV infection, but only a few patients infected with HCV develop porphyria)
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The mechanisms are uncertain.
Up to 20% of patients with alcoholic liver disease harbor HCV. The reasons for this high association are unclear because concomitant alcohol and drug use accounts for only a portion of cases. In these patients, HCV and alcohol act synergistically to worsen liver inflammation and fibrosis.
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Causes of hepatitis

Causes of hepatitis meaning & definition 1 of Causes of hepatitis.

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