Acute myeloid leukemia (aml)

[Cami]

Acute myeloid leukemia is a life-threatening disease in which the cells that normally develop into neutrophils, basophils, eosinophils, and monocytes become cancerous and rapidly replace normal cells in the bone marrow.

People may be tired or pale, may be easily susceptible to infection and fever, and may bruise or bleed easily.
Blood tests and bone marrow examination are needed for diagnosis.
Treatment includes chemotherapy to achieve remission plus additional chemotherapy to avoid relapse and sometimes stem cell transplantation.

Acute myeloid leukemia (AML) is the most common type of leukemia among adults, although it affects people of all ages. AML sometimes is caused by chemotherapy or radiation therapy given to treat another cancer.
In AML, immature leukemia cells rapidly accumulate in the bone marrow, destroying and replacing cells that produce normal blood cells. The leukemia cells are released into the bloodstream and are transported to other organs, where they continue to grow and divide.
There are several subtypes of AML, which are identified based on characteristics of the leukemia cells.
Acute promyelocytic leukemia is an important subtype of AML. In this subtype, chromosomal changes in promyelocytes—cells that are at an early stage in the development into mature neutrophils—allow accumulation of these immature cells.