Overview of platelet disorders


  • Platelets (sometimes called thrombocytes) are cell fragments that circulate in the bloodstream and help blood to clot. Thrombopoietin, primarily produced in the liver, stimulates the bone marrow to make large cells (megakaryocytes), which in turn make platelets from their cytoplasm. Platelets that are not used in clots circulate for 7 to 10 days and are then destroyed. About one third are always stored in the spleen.
    The platelet count (number of platelets circulating in the bloodstream) is usually about 140,000 to 440,000 platelets per microliter (140


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