Pancreas transplantation

[Greta]

Pancreas transplantation is the removal of a healthy pancreas from a recently deceased person or rarely a part of a pancreas from a living person and its transfer into person with severe diabetes whose pancreas no longer makes sufficient insulin.
(See also Overview of Transplantation.)
Pancreas transplantation is done for people who have diabetes if their pancreas cannot make enough insulin . More than 80% of people who have diabetes and who receive a pancreas transplant have normal blood sugar levels afterward and no longer need insulin , but they trade this benefit for the need to take immunosuppressants, with the risk of infections and other side effects.
Because injectable insulin is a safe and reasonably effective treatment for diabetes, freedom from insulin is not considered a sufficient reason for pancreas transplantation. Thus, this procedure is usually done only in people with diabetes if:

They also have kidney failure.
They cannot keep their blood sugar levels within an acceptable range, particularly if they do not sense when their blood sugar levels become too low.

(Occasionally, when blood sugar levels remain too low for too long, organs, including the brain, are permanently damaged.)
Overall, more than 90% of people who receive a pancreas transplant receive a kidney transplant at the same time. Kidney transplantation requires abdominal surgery and the use of immunosuppressants afterward, so transplanting a pancreas at the same time adds few risks.
Pancreas transplantation may be beneficial for people who are taking insulin but still have high blood sugar levels and whose blood sugar levels become dangerously low after taking insulin.
Sometimes only certain cells from the pancreas are transplanted (called pancreatic islet cell transplantation).
More than 95% of people survive at least 1 year after transplantation.