Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Shrinking
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from Shrink. Shrinking head (Founding), a body of molten metalconnected with a mold for the purpose of supplying metal tocompensate for the shrinkage of the casting; -- called also sinkinghead, and riser.
Shrinking meaning & definition 1 of Shrinking.
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Shrinking is when you're high, stoning and listening to music, usually reggea.
Shrinking meaning & definition 2 of Shrinking.
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Becoming smaller in size or amount.
Shrinking meaning & definition 3 of Shrinking.
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To [drink] and [shop] at [the same] time.
Shrinking meaning & definition 4 of Shrinking.
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