Lip sores, lip inflammation, and other changes

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The lips may undergo changes in size, color, and surface. Some of these changes may indicate a medical problem. Other changes are harmless. With aging, the lips may grow thinner.
Lip sores (ulcers) have various causes. A lip sore with hard edges may be a form of skin cancer (see Types of Oral Cancer; see also Lips and Sun Damage). Sores may also develop as a symptom of other medical conditions, such as erythema multiforme, recurrent oral herpes simplex virus infection (cold sores), or syphilis.
Spots on the lips may occur. Multiple, small, scattered brownish-black spots may be a sign of a hereditary disease called Peutz-Jeghers syndrome, in which polyps form in the stomach and intestines. Rarely, smokers develop noncancerous brown spots on the lips near where the cigarette is held. Freckles and irregularly shaped brownish areas (melanotic macules) are common around the lips and may last for many years. These marks are not cause for concern.
Kawasaki disease, a disease of unknown cause that usually occurs in infants and children 8 years old or younger, can cause dryness and cracking of the lips and reddening of the lining of the mouth.
Other common lip changes include

Sun damage
Lip swelling