Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Chain pump
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A pump consisting of an endless chain, running over a drum orwheel by which it is moved, and dipping below the water to be raised.The chain has at intervals disks or lifts which fit the tube throughwhich the ascending part passes and carry the water to the point ofdischarge.
Chain pump meaning & definition 1 of Chain pump.
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