Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Pumped
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All fired up.
Getting ready to kick ass, or someone ass.
Exhilarated.
Pumped meaning & definition 1 of Pumped.
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pumped is a feeling of total excitment also known as pshyed,amped,rush,
Pumped meaning & definition 2 of Pumped.
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The muscle sensation one feels after doing a set at the gym. The muscles are tight and are larger because they have literally been pumped with blood.
Pumped meaning & definition 3 of Pumped.
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To Be Made Sweet Love To
Pumped meaning & definition 4 of Pumped.
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To absolutely destroy an opposition in any type of team altercation
Pumped meaning & definition 5 of Pumped.
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One who is pumped up, of a muscular figure with an adrenaline rush to match.
Pumped meaning & definition 6 of Pumped.
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When someone is pumped they are very drunk. Comes from getting your stomach pumped.
Pumped meaning & definition 7 of Pumped.
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To be defeated soundly.
To suffer a defeat against an overwhelming force, putting up little or no perceived resistance.Pumped meaning & definition 8 of Pumped.
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Getting it in the rombo from a big black guy.
Pumped meaning & definition 9 of Pumped.
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for one man to have rough anal sex with another man, not necesarily consensual
Pumped meaning & definition 10 of Pumped.
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Scots for [shagged]
Pumped meaning & definition 11 of Pumped.