Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Turn on
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A turn on is something that makes you really excited or really horny. when youre with your lover..it makes you want more.
Turn on meaning & definition 1 of Turn on.
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Anything that one finds appealing, especially those things that a person(male or female) finds to be sexually stimulating, arousing.
Turn on meaning & definition 2 of Turn on.
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1.To open your awareness.
2.Something that just interest you or makes you happy.
Not just a sexual term. Anyone from the 60s used this term prevalently through out the grooviest time in our recent history.
Timothy Leary Turn on, Tune in, drop out.Turn on meaning & definition 3 of Turn on.
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To put on a pair of sneakers or footwear
Turn on meaning & definition 4 of Turn on.
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[Vicki] the most [fucking hot] [women] in the world
Turn on meaning & definition 5 of Turn on.
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