Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Lude
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A Quaalude (a tranquilizer, downer), or an abbreviation for a Honda Prelude (but only by the younger generation). Contrary to the belief of some idiots, it is not the word for crass behavior. That would be LEWD, you tools.
Lude meaning & definition 1 of Lude.
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Abbreviation for the pharmeceutical named Quaalude. It was used in the 1960s and 1970s as an anxiolytic, for the treatment of insomnia, and as a sedative. It became highly popular for recreational use in the 1980s, particularly in California. The active ingredient is Methaqualone, a depressant which is now a schedule 1 substance in the United States. It is still available for prescription in Canada.
Lude meaning & definition 2 of Lude.
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Quaalude
Lude meaning & definition 3 of Lude.
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