Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Smokehouse
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A building where meat or fish is cured by subjecting it to adense smoke.
Smokehouse meaning & definition 1 of Smokehouse.
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A nickname for a dark skinned man with a long penis. Named because his schlong looks like a sausage that one would find hanging in a smokehouse.
Smokehouse meaning & definition 2 of Smokehouse.
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Homosexual male...One who hangs meat in mouth.
Smokehouse meaning & definition 3 of Smokehouse.
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Verb : To get trash from a restaraunt joint's dumpster and spread that shit in someone's yard. A substitute for tee-peeing.
Smokehouse meaning & definition 4 of Smokehouse.
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A shed or room for curing food by exposure to smoke.
Smokehouse meaning & definition 5 of Smokehouse.
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(V). An extremely attractive female. Refers to her being [smokin] hot. Is used when classifying [someones] [attractiveness].
Smokehouse meaning & definition 6 of Smokehouse.
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