Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Scunner
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To cause to loathe, or feel disgust at. [Scot.
Scunner meaning & definition 1 of Scunner.
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Scots word:-
Something that makes you feel sick.Scunner meaning & definition 2 of Scunner.
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Downer / depresing. e.g missed the last bus home and had to get a taxi, cost me £20 ..reply..
Scunner meaning & definition 3 of Scunner.
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A menacing youth with very bad dress sense and uncouth nature.See also [chav] or [scally].
Scunner meaning & definition 4 of Scunner.
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A person of no moral background.Found drinking,smoking,unemployed on council estates in England.
Scunner meaning & definition 5 of Scunner.
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twat
Scunner meaning & definition 6 of Scunner.
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Chav or chavette or any other type of tosser
Scunner meaning & definition 7 of Scunner.
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A stunning ('stunner') boy or girl from Scunthorpe.
Scunner meaning & definition 8 of Scunner.
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Someone who'd gi'e ye the pip!
Scunner meaning & definition 9 of Scunner.
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A strong dislike.
Scunner meaning & definition 10 of Scunner.
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