Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Walnuts
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Another name for John McCain.
Walnuts meaning & definition 1 of Walnuts.
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Adjective.
Kind of like nuts, but way more nuts.
Walnuts meaning & definition 2 of Walnuts.
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When your nuts are a little sweaty so they stick to the side of your leg. The pre-cursor to itchy nuts.
Walnuts meaning & definition 3 of Walnuts.
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A pair of testicles placed [flush] against a [vertical] [plane].
Walnuts meaning & definition 4 of Walnuts.
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a nut with a slightly bitter taste, a series of folds in it, and a hard shell:
Walnuts meaning & definition 5 of Walnuts.
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