Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Whinger
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A kind of hanger or sword used as a knife at meals and as aweapon. [Scot.
Whinger meaning & definition 1 of Whinger.
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slang for someone who won't shut up.
to whinge
to be a whingerties in with whiner
sometimes refered to as a karade
Whinger meaning & definition 2 of Whinger.
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Someone who is always complaining
Whinger meaning & definition 3 of Whinger.
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Someone to complains about everything.
A person who bitches about fucking everything.
A pussy.Whinger meaning & definition 4 of Whinger.
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a person who complains repeatedly:
Whinger meaning & definition 5 of Whinger.
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